Louisville defeated Georgia Tech 75-48 in its inaugural game in the Atlantic Coast Conference on Friday night at the KFC YUM! Center.
Mariya Moore led the Cardinals (13-1) with 22 points, eight assists and four rebounds.
Bria Smith added nine points and eight rebounds while Emmonni Henderson came off the bench and contributed with eight points and six rebounds.
Louisville held a 22-20 lead with 4:30 left in the first half before going on an 11-0 run to take control of the game.
Georgia Tech (10-5) All-American guard Kaela Davis was held in check throughout the night, shooting 2 of 15 from the field and scoring 11 points.
Louisville will play at Pittsburgh on Sunday.