Louisville improved to 6-0 on the season after a 102-61 victory over Lafayette on Friday night at the KFC YUM! Center.
Myisha Hines-Allen led Louisville with 18 points while six other Cardinals joined her in double figure scoring.
Jude Schimmel hit 4-of-5 three-pointers and scored 15 points. Mariya Moore finished with 11 points and 10 assists.
With 12:43 left in the first half, Louisville trailed Lafayette 20-18, but went on a 28-2 run over the next seven minutes to take control of the game.
The Cardinals went into halftime leading 56-28, their highest first half point total of the season.
Emmonni Henderson scored eight of her 13 points in the second half as Louisville cruised to another easy victory.
Louisville will travel to Valparaiso on Sunday.